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  • Through the acquisition of CoreBiome - a microbiome analysis company focused on accelerating discovery for customers in medical, pharmaceutical, agricultural and academic research - DNA Genotek offers comprehensive services for microbiome sample processing, sequencing, and bioinformatic analysis.

    CoreBiome offers microbial profiling of all sample types, including the complete line of DNA Genotek’s OMNIgene® collection devices as well as a broad range of high, medium and low microbial biomass sample types.

    Variable-depth shotgun metagenomics

    16S sequencing for low-biomass samples

    WGS of microbial isolates

    Innovative data analysis

    Custom analysis and report

    High-resolution shotgun metagenomics

    Affordable variable-depth shotgun metagenomics for large microbiome studies, providing species-level resolution and functional profiles.

    BoosterShot is our innovative alternative to amplicon sequencing for large-scale microbiome experimentation, starting at 2 million sequences per sample.

    BoosterShot uses shotgun sequencing to generate accurate taxonomic and functional profiles of the microbiome with species-level resolution. Based on algorithms of unparalleled sensitivity and proprietary genomics techniques, BoosterShot recovers the full species-level taxonomic and functional repertoire of a complex microbiome at dramatically lower cost than deep shotgun sequencing. BoosterShot achieves this performance by converting random DNA sequences into direct gene and species-level markers.

    BoosterShot is recommended for human stool and oral microbiomes, which are low in host DNA contamination, and which are well represented in whole-genome reference databases. It may still provide useful information that is complementary to 16S in other environments.

    Deliverables include raw sequencing data (FASTQ), Trimmed and stitched sequences (FASTA), taxonomy and function tables, quality-control dashboard, standard CorePlus analysis. Click here for an example report.

    World-leading 16S assay for low biomass samples

    16S sequencing using improved protocols to detect more species and reduce bias over standard 16S methods for any environment.

    BenchMark is a 16S rRNA gene-based assay for microbiome profiling. Based on University of Minnesota technology, BenchMark uses a combination of real-time PCR sample quantification, dual-indexed multiplexing, and optimized enzymatic and PCR conditions to eliminate most of the taxonomic dropout that is observed with “standard” 16S methods.

    BenchMark suppresses chimera formation and minimizes PCR error, resulting in greater accuracy when tested head-to-head against other 16S methods in the analysis of defined mock community standards.

    BenchMark is recommended for microbiome samples containing high host DNA contamination, or poor representation in whole-genome reference databases, such as those from soil, water, plants, or animals.

    Deliverables include raw sequencing data (FASTQ), Trimmed and stitched sequences (FASTA), taxonomy and predicted function tables, quality-control dashboard, standard CorePlus analysis. Click here for an example report (CorePlus analysis charged separately).

    Large-scale whole-genome sequencing of microbial isolates

    High-throughput strain sequencing and comparative genomics. Characterize your entire strain bank faster than you can say "Sanger sequencing".

    StrainView allows characterization of your entire strain bank with 99% coverage of novel genes and genomes. We combine our proprietary efficient library preparation protocols with optimal alignment-based database search to deliver genome assemblies for single-isolate samples and visualizations of shared genome content across your strains.

    Deliverables include raw sequencing data (FASTQ), Trimmed and stitched sequences (FASTA), taxonomy and annotated function tables, antibiotic resistance gene profiles, virulence gene profiles, quality-control dashboard, and standard data visualizations. Click here for an example report.

    Innovative data analysis for biomarker discovery

    Core Analysis provides customers with full primary data analysis and annotation, including closed-reference operational taxonomic unit (OTU) tables, genus-level taxonomy, species-level taxonomy where available, KEGG metabolic pathway and module tables predicted using the PICRUSt tool, beta diversity analyses (genus-level Bray-Curtis distances, OTU-level weighted and unweighted UniFrac distances), and alpha diversity analysis (Shannon, Simpson, Chao1, and whole-tree phylogenetic diversity). Customers also have access to raw demultiplexed sequencing data.

    Advanced informatics services and custom analysis

    CorePlus Analysis gives our customers full bioinformatics service for biomarker discovery and predictive modeling using statistics and machine learning. Our microbiome analysis experts work directly with customers to develop an analysis plan that meets the customers' scientific goals. Customers receive a custom report containing significant findings, differentiated biomarkers, and publication-ready data visualization figures.

    Other services

    DNA Extraction

    Absolute Quantification

    qPCR-based microbial quantification for absolute abundance profiling

    Deep Sequencing

    Deep shotgun sequencing using single or paired end sequencing

    Services for research use only applications.

    Inside DNA Genotek

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    Contact us

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    Phone

    +1 (613) 723-5757

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    info@dnagenotek.com

    Address

    3000 - 500 Palladium Drive
    Ottawa, Ontario, Canada
    K2V 1C2

    DNA Genotek Inc., a subsidiary of OraSure Technologies, Inc. (NASDAQ: OSUR), focuses on providing high-quality biological sample collection products and end-to-end services for human genomics, microbiome and infectious disease applications. The Company's Oragene•Dx and ORAcollect•Dx product lines are the first and only FDA 510(k) cleared saliva-based DNA collection devices for in vitro diagnostic use. DNA Genotek also offers Research Use Only products to collect and preserve large amounts of DNA or RNA from multiple sample types. DNA Genotek markets its products worldwide and has a global customer base with thousands of customers in over 100 countries.

    © 2019 DNA Genotek Inc., a subsidiary of OraSure Technologies, Inc., all rights reserved.

  • Industry Solutions
    • Human Genomics - Academic Research
    • Human Genomics - Clinical Diagnostics
    • Microbiome - Academic Research
    • Clinical Microbiome
    • Infectious Disease
    • Biobanking
    • Animal
    • H L A Typing
  • Products
    • Human Genomics Collection Kits
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        • All DNA & RNA Collection Kits (saliva)
          • Oragene•DNA | 600 Series
          • Oragene•DNA | 500 Series
          • ORAcollect for Pediatrics | OC-175
          • Oragene•RNA | RE-100
      • Clinical Diagnostics
        • All DNA Collection Kits (saliva)
          • Oragene•DNA | 600 Series
          • Oragene•DNA | 500 Series
          • Oragene•ONE | ON-600
          • Oragene•ONE | ON-500
          • ORAcollect•DNA | OCR-100
      • Reagents
        • prepIT•L2P | PT-L2P (saliva)
        • HEMAgene | HG-BCD (blood)
    • Microbiome Collection Kits
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        • All microbiome products list
        • OMNIgene•GUT | OM-200 (feces)
        • OMNIgene•ORAL | OM-501 (saliva)
        • OMNIgene•ORAL | OM-505 (saliva)
        • OMNIgene•ORAL | OMR-110 (gum/plaque)
        • OMNIgene•ORAL | OMR-120 (tongue)
        • OMNIgene•VAGINAL | OMR-130
      • Clinical Microbiome
        • OMNIgene•GUT | OM-200 (feces)
    • Infectious Disease Collection Kits
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        • prepIT•L2P | PT-L2P (saliva)
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